Compound Detail
CHEMBL1271777
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Basic Information
| ChEMBL ID | CHEMBL1271777 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KBHJILJMALXJKR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
394.4
MW (Da)
4.85
ALogP
5
HBA
2
HBD
83.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 7.89 | 7.89 | 13.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of p38alpha by immunosorbent based assay | 20934337 |
| Mitogen-activated protein kinase 14 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of p38-alpha MAPK (unknown origin) after 3 hrs | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1039/C0MD00228C | Mitogen-activated protein kinase 14 | 2 |
| 20934337 | 10.1016/j.bmcl.2010.09.012 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine