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Assay Detail

CHEMBL3222289

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of p38-alpha MAPK (unknown origin) after 3 hrs
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Mitogen-activated protein kinase 14 (CHEMBL260)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformational effects on potency of thioimidazoles and dihydrothiazolines
Selig R, Schattel V, Goettert M, Schollmeyer D, Albrecht W, Laufer S
Medchemcomm (2011) 2 : 261 -269
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.19 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1271554 1 8.05
CHEMBL1271777 1 7.89
CHEMBL1271555 1 7.85
CHEMBL10 SB-203580 1 7.72
CHEMBL3218973 1 7.72
CHEMBL3219237 1 7.70
CHEMBL3218963 1 7.70
CHEMBL3218974 1 7.66
CHEMBL3218962 1 7.54
CHEMBL3218965 1 7.44
CHEMBL3219238 1 7.36
CHEMBL3218960 1 7.34
CHEMBL3218959 1 7.34
CHEMBL1271663 1 7.28
CHEMBL3218958 1 7.08
CHEMBL3218964 1 6.94
CHEMBL1272216 1 6.88
CHEMBL3218961 1 6.85
CHEMBL3218968 1 6.76
CHEMBL3218970 1 6.73
CHEMBL3218966 1 6.47
CHEMBL3218972 1 6.40
CHEMBL3218969 1 6.39
CHEMBL3218971 1 6.37
CHEMBL3218967 1 6.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1271554 IC50 = 9.0 nM 8.05
CHEMBL1271777 IC50 = 13.0 nM 7.89
CHEMBL1271555 IC50 = 14.0 nM 7.85
CHEMBL10 SB-203580 IC50 = 19.0 nM 7.72
CHEMBL3218973 IC50 = 19.0 nM 7.72
CHEMBL3219237 IC50 = 20.0 nM 7.70
CHEMBL3218963 IC50 = 20.0 nM 7.70
CHEMBL3218974 IC50 = 22.0 nM 7.66
CHEMBL3218962 IC50 = 29.0 nM 7.54
CHEMBL3218965 IC50 = 36.0 nM 7.44
CHEMBL3219238 IC50 = 44.0 nM 7.36
CHEMBL3218960 IC50 = 46.0 nM 7.34
CHEMBL3218959 IC50 = 46.0 nM 7.34
CHEMBL1271663 IC50 = 53.0 nM 7.28
CHEMBL3218958 IC50 = 83.0 nM 7.08
CHEMBL3218964 IC50 = 115.0 nM 6.94
CHEMBL1272216 IC50 = 133.0 nM 6.88
CHEMBL3218961 IC50 = 140.0 nM 6.85
CHEMBL3218968 IC50 = 173.0 nM 6.76
CHEMBL3218970 IC50 = 186.0 nM 6.73
CHEMBL3218966 IC50 = 337.0 nM 6.47
CHEMBL3218972 IC50 = 396.0 nM 6.40
CHEMBL3218969 IC50 = 411.0 nM 6.39
CHEMBL3218971 IC50 = 430.0 nM 6.37
CHEMBL3218967 IC50 = 498.0 nM 6.30