Compound Detail
CHEMBL1271554
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Basic Information
| ChEMBL ID | CHEMBL1271554 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IUCRTXMTGDSAKX-UHFFFAOYSA-N |
1
Targets
4
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
436.5
MW (Da)
5.32
ALogP
4
HBA
2
HBD
70.7
PSA (Ų)
0.40
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.05 | 7.42 | 9.0 | 4 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of p38alpha by immunosorbent based assay | 20934337 |
| Mitogen-activated protein kinase 14 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of... | 21449619 |
| Mitogen-activated protein kinase 14 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of p38-alpha MAPK (unknown origin) after 3 hrs | - |
| Mitogen-activated protein kinase 14 | IC50 | = | 2980.0 | nM | 5.53 | Inhibition of p38 alpha MAPK in human whole blood assessed as suppression of LPS... | 21449619 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21449619 | 10.1021/jm101623p | Mitogen-activated protein kinase 14 | 4 |
| - | 10.1039/C0MD00228C | Mitogen-activated protein kinase 14 | 2 |
| 20934337 | 10.1016/j.bmcl.2010.09.012 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine