Assay Detail
Binding
CHEMBL1776378
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of ATF-2 by immunosorbent non-radioactive enzyme assay
49
Total Activities
49
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Chiral sulfoxides as metabolites of 2-thioimidazole-based p38α mitogen-activated protein kinase inhibitors: enantioselective synthesis and biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 49 | 7.45 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1773433 | — | — | 1 | 8.70 |
| CHEMBL1773432 | — | — | 1 | 8.70 |
| CHEMBL1773437 | — | — | 1 | 8.52 |
| CHEMBL1773436 | — | — | 1 | 8.40 |
| CHEMBL1773438 | — | — | 1 | 8.40 |
| CHEMBL480962 | — | — | 1 | 8.30 |
| CHEMBL1773499 | — | — | 1 | 8.22 |
| CHEMBL1271554 | — | — | 1 | 8.05 |
| CHEMBL1773506 | — | — | 1 | 7.96 |
| CHEMBL1773503 | — | — | 1 | 7.96 |
| CHEMBL1773502 | — | — | 1 | 7.92 |
| CHEMBL1773505 | — | — | 1 | 7.92 |
| CHEMBL1773434 | — | — | 1 | 7.92 |
| CHEMBL10 | SB-203580 | — | 1 | 7.82 |
| CHEMBL1773509 | — | — | 1 | 7.77 |
| CHEMBL1773421 | — | — | 1 | 7.75 |
| CHEMBL1773510 | — | — | 1 | 7.72 |
| CHEMBL1773504 | — | — | 1 | 7.68 |
| CHEMBL1773435 | — | — | 1 | 7.62 |
| CHEMBL1773520 | — | — | 1 | 7.60 |
| CHEMBL1773508 | — | — | 1 | 7.58 |
| CHEMBL482086 | — | — | 1 | 7.57 |
| CHEMBL1773511 | — | — | 1 | 7.57 |
| CHEMBL1773500 | — | — | 1 | 7.54 |
| CHEMBL1773514 | — | — | 1 | 7.51 |
| CHEMBL1773439 | — | — | 1 | 7.47 |
| CHEMBL1773507 | — | — | 1 | 7.47 |
| CHEMBL1773515 | — | — | 1 | 7.44 |
| CHEMBL1773425 | — | — | 1 | 7.43 |
| CHEMBL1773512 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1773433 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1773432 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL1773437 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL1773436 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL1773438 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL480962 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL1773499 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL1271554 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1773506 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1773503 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1773502 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1773505 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL1773434 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL10 | SB-203580 | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL1773509 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL1773421 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL1773510 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL1773504 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL1773435 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL1773520 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL1773508 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL482086 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1773511 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL1773500 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL1773514 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL1773507 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1773439 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL1773515 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL1773425 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL1773512 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1773521 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL1773501 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL321415 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL1773513 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL109331 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL1773429 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL1773430 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL1773519 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL1773431 | — | IC50 | = | 141.0 | nM | 6.85 |
| CHEMBL1773427 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL1773517 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL432798 | — | IC50 | = | 188.0 | nM | 6.73 |
| CHEMBL1773428 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL1773518 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL1773516 | — | IC50 | = | 207.0 | nM | 6.68 |
| CHEMBL1773426 | — | IC50 | = | 403.0 | nM | 6.39 |
| CHEMBL1773423 | — | IC50 | = | 1030.0 | nM | 5.99 |
| CHEMBL1773422 | — | IC50 | = | 1072.0 | nM | 5.97 |
| CHEMBL1773424 | — | IC50 | = | 1265.0 | nM | 5.90 |