Compound Detail
CHEMBL1773424
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Basic Information
| ChEMBL ID | CHEMBL1773424 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DRMJRHUMYBYDIX-SANMLTNESA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
372.4
MW (Da)
2.98
ALogP
5
HBA
1
HBD
82.9
PSA (Ų)
0.71
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 5.9 | 5.9 | 1265.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 1265.0 | nM | 5.9 | Inhibition of p38 alpha MAPK in human whole blood assessed as phosphorylation of... | 21449619 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 21449619 | 10.1021/jm101623p | Mitogen-activated protein kinase 14 | 3 |
| 28613871 | 10.1021/acs.jmedchem.6b01647 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine