Compound Detail
CHEMBL128317
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O=C(O)Cc1ccc(CCNS(=O)(=O)c2ccc3ccc(OCc4ccc5ccccc5n4)cc3c2)cc1
Basic Information
| ChEMBL ID | CHEMBL128317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VLVJCIWGJOALBA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
526.6
MW (Da)
5.12
ALogP
5
HBA
2
HBD
105.6
PSA (Ų)
0.26
QED
2
Ro5 Violations
10
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.62
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 CHEMBL5645 | Ki | 8.62 | 8.62 | 2.4 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cysteinyl leukotriene receptor 1 | Ki | = | 2.4 | nM | 8.62 | In vitro binding affinity towards Cysteinyl leukotriene D4 receptor by using [3H... | 10669566 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10669566 | 10.1021/jm990387k | Cysteinyl leukotriene receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine