Assay Detail
Binding
CHEMBL663972
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity towards Cysteinyl leukotriene D4 receptor by using [3H]LTD4 binding assay in guinea pig lung membranes
53
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Lung |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Derivation of pharmacophore and CoMFA models for leukotriene D(4) receptor antagonists of the quinolinyl(bridged)aryl series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 53 | 7.61 | 8.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132162 | — | — | 1 | 8.98 |
| CHEMBL131611 | — | — | 1 | 8.82 |
| CHEMBL787 | MONTELUKAST | 4.0 | 1 | 8.68 |
| CHEMBL128317 | — | — | 1 | 8.62 |
| CHEMBL128583 | — | — | 1 | 8.59 |
| CHEMBL130846 | — | — | 1 | 8.57 |
| CHEMBL423333 | — | — | 1 | 8.47 |
| CHEMBL128641 | — | — | 1 | 8.42 |
| CHEMBL336298 | — | — | 1 | 8.40 |
| CHEMBL335000 | — | — | 1 | 8.39 |
| CHEMBL419796 | — | — | 1 | 8.34 |
| CHEMBL128794 | — | — | 1 | 8.32 |
| CHEMBL128068 | — | — | 1 | 8.26 |
| CHEMBL131304 | — | — | 1 | 8.25 |
| CHEMBL128364 | — | — | 1 | 8.14 |
| CHEMBL127842 | — | — | 1 | 8.14 |
| CHEMBL128477 | — | — | 1 | 8.11 |
| CHEMBL337195 | — | — | 1 | 8.08 |
| CHEMBL132167 | — | — | 1 | 8.05 |
| CHEMBL422609 | — | — | 1 | 8.04 |
| CHEMBL128483 | — | — | 1 | 7.92 |
| CHEMBL130384 | — | — | 1 | 7.89 |
| CHEMBL341172 | — | — | 1 | 7.89 |
| CHEMBL127665 | — | — | 1 | 7.82 |
| CHEMBL434992 | — | — | 1 | 7.82 |
| CHEMBL339716 | — | — | 1 | 7.68 |
| CHEMBL129893 | — | — | 1 | 7.55 |
| CHEMBL131008 | — | — | 1 | 7.54 |
| CHEMBL131025 | — | — | 1 | 7.52 |
| CHEMBL129079 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132162 | — | Ki | = | 1.05 | nM | 8.98 |
| CHEMBL131611 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL787 | MONTELUKAST | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL128317 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL128583 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL130846 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL423333 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL128641 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL336298 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL335000 | — | Ki | = | 4.1 | nM | 8.39 |
| CHEMBL419796 | — | Ki | = | 4.6 | nM | 8.34 |
| CHEMBL128794 | — | Ki | = | 4.8 | nM | 8.32 |
| CHEMBL128068 | — | Ki | = | 5.5 | nM | 8.26 |
| CHEMBL131304 | — | Ki | = | 5.6 | nM | 8.25 |
| CHEMBL127842 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL128364 | — | Ki | = | 7.3 | nM | 8.14 |
| CHEMBL128477 | — | Ki | = | 7.8 | nM | 8.11 |
| CHEMBL337195 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL132167 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL422609 | — | Ki | = | 9.2 | nM | 8.04 |
| CHEMBL128483 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL130384 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL341172 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL127665 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL434992 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL339716 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL129893 | — | Ki | = | 28.0 | nM | 7.55 |
| CHEMBL131008 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL131025 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL129079 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL128771 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL337162 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL129866 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL128164 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL131345 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL128151 | — | Ki | = | 44.0 | nM | 7.36 |
| CHEMBL336606 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL131166 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL132341 | — | Ki | = | 79.0 | nM | 7.10 |
| CHEMBL131287 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL129142 | — | Ki | = | 88.0 | nM | 7.06 |
| CHEMBL131266 | — | Ki | = | 108.0 | nM | 6.97 |
| CHEMBL130442 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL131934 | — | Ki | = | 134.0 | nM | 6.87 |
| CHEMBL127162 | — | Ki | = | 168.0 | nM | 6.78 |
| CHEMBL128697 | — | Ki | = | 190.0 | nM | 6.72 |
| CHEMBL128548 | — | Ki | = | 237.0 | nM | 6.62 |
| CHEMBL131582 | — | Ki | = | 250.0 | nM | 6.60 |
| CHEMBL129570 | — | Ki | = | 297.0 | nM | 6.53 |
| CHEMBL128531 | — | Ki | = | 360.0 | nM | 6.44 |