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Compound Detail

CHEMBL128786

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COc1ccccc1CN1CCC(C2CCN(C)CC2)CC1

Basic Information

ChEMBL ID CHEMBL128786
Phase Preclinical
Structure Type MOL
InChI Key JGUYPHCIIOXIMF-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names

Molecular Properties

302.5
MW (Da)
3.25
ALogP
3
HBA
0
HBD
15.7
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H30N2O
MW 302.46
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.75

Activity Summary

EC50 1 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cavia porcellus
CHEMBL369
EC50 9.22 9.22 0.6 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cavia porcellus EC50 = 0.6026 nM 9.22 Inotropic responses, induced by the compound in electrically paced (Hz) guinea p... 11708906

Literature References

PubMed DOI Target Context # Activities
11708906 10.1021/jm0155594 Cavia porcellus 2
11708906 10.1021/jm0155594 Muscarinic acetylcholine receptor M1 1
11708906 10.1021/jm0155594 Muscarinic acetylcholine receptor M2 1
11708906 10.1021/jm0155594 Muscarinic acetylcholine receptor M3 1
11708906 10.1021/jm0155594 Muscarinic acetylcholine receptor M4 1
11708906 10.1021/jm0155594 Muscarinic acetylcholine receptor M5 1

Data from ChEMBL 36 via Core Engine