Assay Detail
Functional
CHEMBL858105
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inotropic responses, induced by the compound in electrically paced (Hz) guinea pig left atria
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological activity of methoctramine-related polyamines as putative G(i) protein activators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 9.15 | 9.65 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | — | 1 | 9.65 |
| CHEMBL129680 | — | — | 1 | 9.47 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | — | 1 | 9.40 |
| CHEMBL340804 | — | — | 1 | 9.28 |
| CHEMBL128786 | — | — | 1 | 9.22 |
| CHEMBL128493 | — | — | 1 | 8.89 |
| CHEMBL128365 | ARECAIDINE PROPARGYL ESTER | — | 1 | 8.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127273 | PIPERTRAMINE | EC50 | = | 0.2239 | nM | 9.65 |
| CHEMBL129680 | — | EC50 | = | 0.3388 | nM | 9.47 |
| CHEMBL130835 | PIPERTRAMINE AMIDE | EC50 | = | 0.3981 | nM | 9.40 |
| CHEMBL340804 | — | EC50 | = | 0.5248 | nM | 9.28 |
| CHEMBL128786 | — | EC50 | = | 0.6026 | nM | 9.22 |
| CHEMBL128493 | — | EC50 | = | 1.288 | nM | 8.89 |
| CHEMBL128365 | ARECAIDINE PROPARGYL ESTER | EC50 | = | 7.079 | nM | 8.15 |