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Compound Detail

CHEMBL1303785

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O=C(Nc1ncc(Cc2ccccc2Cl)s1)C1=NCCN1

Basic Information

ChEMBL ID CHEMBL1303785
Phase Preclinical
Structure Type MOL
InChI Key IOQOTMJQIOAEGE-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

320.8
MW (Da)
2.33
ALogP
5
HBA
2
HBD
66.4
PSA (Ų)
0.91
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H13ClN4OS
MW 320.81
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -1.93

Activity Summary

IC50 2 meas. best 6.37

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
IC50 6.37 5.9 430.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine