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Compound Detail

CHEMBL1314749

DECAHYDROGAMBOGIC ACID
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CC(C)CCCC1(C)C=Cc2c(O)c3c(c(CCC(C)C)c2O1)OC12C(CC4CC1C(C)(C)OC2(CCC(C)C(=O)O)C4O)C3=O

Basic Information

ChEMBL ID CHEMBL1314749
Name DECAHYDROGAMBOGIC ACID
Phase Preclinical
Structure Type MOL
InChI Key ZZGVJHSBRGZEML-UHFFFAOYSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

638.8
MW (Da)
7.35
ALogP
7
HBA
3
HBD
122.5
PSA (Ų)
0.23
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C38H54O8
MW 638.84
Aromatic Rings 1
Heavy Atoms 46
NP-Likeness 2.50

Activity Summary

IC50 2 meas. best 5.94
Ki 2 meas. best 6.21

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.21 6.21 620.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.94 5.94 1148.2 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.75 5.75 1770.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.64 5.64 2290.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine