Compound Detail
CHEMBL132673
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Basic Information
| ChEMBL ID | CHEMBL132673 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JUYCSVXBPHVEGT-UHFFFAOYSA-M |
| Parent Compound | CHEMBL1180572 |
| Active Moiety | CHEMBL1180572 |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
514.9
MW (Da)
8.09
ALogP
4
HBA
0
HBD
44.8
PSA (Ų)
0.06
QED
2
Ro5 Violations
28
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oryctolagus cuniculus CHEMBL374 | EC50 | 5.1 | 4.66 | 8000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | EC50 | = | 8000.0 | nM | 5.1 | In vivo antagonistic activity against PAF induced platelet aggregation (5 x 10e-... | 3339611 |
| Oryctolagus cuniculus | EC50 | = | 60000.0 | nM | 4.22 | In vivo antagonistic activity against collagen induced platelet aggregation (40 ... | 3339611 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3339611 | 10.1021/jm00397a025 | Cavia porcellus | 9 |
| 3339611 | 10.1021/jm00397a025 | Oryctolagus cuniculus | 4 |
| 3339611 | 10.1021/jm00397a025 | Rattus norvegicus | 2 |
Data from ChEMBL 36 via Core Engine