Assay Detail
Functional
CHEMBL769817
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In vivo antagonistic activity against PAF induced platelet aggregation (5 x 10e-8 M )
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Structure-activity relationship in PAF-acether. 4. Synthesis and biological activities of carboxylate isosteres.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.06 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL422792 | — | — | 1 | 5.82 |
| CHEMBL132673 | — | — | 1 | 5.10 |
| CHEMBL335038 | — | — | 1 | 4.96 |
| CHEMBL133922 | — | — | 1 | 4.89 |
| CHEMBL295212 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL422792 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL132673 | — | EC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL335038 | — | EC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL133922 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL295212 | — | EC50 | = | 30500.0 | nM | 4.52 |