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Compound Detail

CHEMBL1328792

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C=CCOc1c(Cl)cc(CNc2ccc(C)c(Cl)c2)cc1OC

Basic Information

ChEMBL ID CHEMBL1328792
Phase Preclinical
Structure Type MOL
InChI Key XCTYCHCUFZVFGC-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names

Molecular Properties

352.3
MW (Da)
5.49
ALogP
3
HBA
1
HBD
30.5
PSA (Ų)
0.67
QED
1
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19Cl2NO2
MW 352.26
Aromatic Rings 2
Heavy Atoms 23
NP-Likeness -1.11

Activity Summary

EC50 2 meas. best 6.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
EC50 6.31 5.935 491.0 2

Activity Data Samples

Top measurements by pChEMBL value

Data from ChEMBL 36 via Core Engine