Compound Detail
CHEMBL134529
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Basic Information
| ChEMBL ID | CHEMBL134529 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IZZJOGWXTFEDLL-XUUWZHRGSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
237.2
MW (Da)
-2.86
ALogP
7
HBA
5
HBD
128.5
PSA (Ų)
0.35
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 4 meas. best 4.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen phosphorylase, brain form CHEMBL3856 | Ki | 4.1 | 4.1 | 79432.8 | 1 |
| Unchecked CHEMBL612545 | Ki | 4.07 | 4.07 | 85000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen phosphorylase, brain form | Ki | = | 79432.82 | nM | 4.1 | Inhibitory activity against Pig Skeletal Glycogen Phosphorylase b | 12213058 |
| Unchecked | Ki | = | 85000.0 | nM | 4.07 | Inhibition of glycogen phosphorylase b (unknown origin) | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9406599 | 10.1021/jm970273d | Glycogen phosphorylase, muscle form | 1 |
| 9154968 | 10.1021/jm9608016 | Glycogen phosphorylase, brain form | 1 |
| 12213058 | 10.1021/jm020808p | Glycogen phosphorylase, brain form | 1 |
| 22325154 | 10.1016/j.bmc.2011.12.059 | Glycogen phosphorylase, muscle form | 1 |
| - | 10.1007/s00044-013-0812-0 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine