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Assay Detail

CHEMBL680572

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Binding
Inhibitory activity against Pig Skeletal Glycogen Phosphorylase b
ChEMBL ↗
74
Total Activities
73
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Sus scrofa
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Glycogen phosphorylase, brain form (CHEMBL3856) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

DrugScore meets CoMFA: adaptation of fields for molecular comparison (AFMoC) or how to tailor knowledge-based pair-potentials to a particular protein.
Gohlke H, Klebe G.
J Med Chem (2002) 45 : 4153 -4170
PubMed 12213058 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 74 4.85 7.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL335077 — — 1 7.50
CHEMBL3351153 — — 1 6.80
CHEMBL3351144 — — 1 5.50
CHEMBL133097 — — 1 4.80
CHEMBL3351143 — — 1 4.50
CHEMBL3351132 — — 1 4.40
CHEMBL131960 — — 1 4.40
CHEMBL3351142 — — 1 4.40
CHEMBL3351148 — — 1 4.40
CHEMBL3351152 — — 1 4.20
CHEMBL3351140 — — 1 4.10
CHEMBL134529 — — 1 4.10
CHEMBL3351139 — — 1 4.00
CHEMBL135601 — — 1 -
CHEMBL134846 — — 1 -
CHEMBL336170 — — 1 -
CHEMBL3351138 — — 1 -
CHEMBL3351135 — — 1 -
CHEMBL131902 — — 1 -
CHEMBL3351137 — — 1 -
CHEMBL3351141 — — 1 -
CHEMBL132143 — — 1 -
CHEMBL133769 — — 1 -
CHEMBL3351134 — — 1 -
CHEMBL133447 — — 1 -
CHEMBL135302 — — 1 -
CHEMBL133553 — — 1 -
CHEMBL133767 — — 1 -
CHEMBL40654 — — 1 -
CHEMBL133768 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL335077 — Ki = 31.62 nM 7.50
CHEMBL3351153 — Ki = 158.49 nM 6.80
CHEMBL3351144 — Ki = 3162.28 nM 5.50
CHEMBL133097 — Ki = 15848.93 nM 4.80
CHEMBL3351143 — Ki = 31622.78 nM 4.50
CHEMBL131960 — Ki = 39810.72 nM 4.40
CHEMBL3351132 — Ki = 39810.72 nM 4.40
CHEMBL3351148 — Ki = 39810.72 nM 4.40
CHEMBL3351142 — Ki = 39810.72 nM 4.40
CHEMBL3351152 — Ki = 63095.73 nM 4.20
CHEMBL134529 — Ki = 79432.82 nM 4.10
CHEMBL3351140 — Ki = 79432.82 nM 4.10
CHEMBL3351139 — Ki = 100000.0 nM 4.00
CHEMBL3351136 — Ki = 1995262.31 nM -
CHEMBL134478 — Ki = 15848931.92 nM -
CHEMBL3351138 — Ki = 125892.54 nM -
CHEMBL132302 — Ki = 15848931.92 nM -
CHEMBL336170 — Ki = 25118864.32 nM -
CHEMBL134846 — Ki = 15848931.92 nM -
CHEMBL135601 — Ki = 199526.23 nM -
CHEMBL1222250 DEXTROSE Ki = 7943282.35 nM -
CHEMBL132094 — Ki = 3981071.71 nM -
CHEMBL335028 — Ki = 15848931.92 nM -
CHEMBL131931 — Ki >= 100000.0 nM -
CHEMBL335777 — Ki = 39810717.06 nM -
CHEMBL1222250 DEXTROSE Ki = 1584893.19 nM -
CHEMBL134270 — Ki = 15848931.92 nM -
CHEMBL132995 — Ki >= 100000.0 nM -
CHEMBL136012 — Ki = 3981071.71 nM -
CHEMBL135181 — Ki = 25118864.32 nM -
CHEMBL134000 — Ki = 398107.17 nM -
CHEMBL133447 — Ki = 10000000.0 nM -
CHEMBL40654 — Ki >= 100000.0 nM -
CHEMBL131799 — Ki = 2511886.43 nM -
CHEMBL3351137 — Ki = 316227.77 nM -
CHEMBL3351141 — Ki = 1000000.0 nM -
CHEMBL1161038 — Ki = 15848931.92 nM -
CHEMBL132143 — Ki = 7943282.35 nM -
CHEMBL133769 — Ki = 25118864.32 nM -
CHEMBL335273 — Ki = 1258925.41 nM -
CHEMBL133768 — Ki = 19952623.15 nM -
CHEMBL133783 — Ki >= 100000.0 nM -
CHEMBL135302 — Ki = 398107.17 nM -
CHEMBL132376 — Ki = 1000000.0 nM -
CHEMBL133553 — Ki = 5011872.34 nM -
CHEMBL133767 — Ki = 3162277.66 nM -
CHEMBL134001 — Ki = 1995262.31 nM -
CHEMBL337281 — Ki = 2511886.43 nM -
CHEMBL3351135 — Ki = 3981071.71 nM -
CHEMBL334990 — Ki = 12589254.12 nM -