Compound Detail
CHEMBL3351152
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Basic Information
| ChEMBL ID | CHEMBL3351152 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BUENWPZCHAHNFK-UGPPFEIVSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
262.2
MW (Da)
-4.60
ALogP
7
HBA
6
HBD
148.3
PSA (Ų)
0.28
QED
1
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 4.23
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | Ki | 4.23 | 4.23 | 59020.1 | 1 |
| Glycogen phosphorylase, brain form CHEMBL3856 | Ki | 4.22 | 4.21 | 59700.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | Ki | = | 59020.11 | nM | 4.23 | Affinity on glycogen phosphorylase (GP) enzyme. | 9435905 |
| Glycogen phosphorylase, brain form | Ki | = | 59700.0 | nM | 4.22 | Inhibition of rabbit glycogen phosphorylase B enzyme | 9154968 |
| Glycogen phosphorylase, brain form | Ki | = | 63095.73 | nM | 4.2 | Inhibitory activity against Pig Skeletal Glycogen Phosphorylase b | 12213058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10966742 | 10.1021/jm000941m | Unchecked | 2 |
| 9406599 | 10.1021/jm970273d | Glycogen phosphorylase, muscle form | 1 |
| 9154968 | 10.1021/jm9608016 | Glycogen phosphorylase, brain form | 1 |
| 12213058 | 10.1021/jm020808p | Glycogen phosphorylase, brain form | 1 |
| 9435905 | 10.1021/jm970488n | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine