Compound Detail
CHEMBL134903
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Basic Information
| ChEMBL ID | CHEMBL134903 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WHUPHUJYROLPBP-CHWSQXEVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
187.3
MW (Da)
2.47
ALogP
1
HBA
1
HBD
12.0
PSA (Ų)
0.66
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.81
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 6.81 | 6.81 | 154.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | IC50 | = | 154.0 | nM | 6.81 | Displacement of [3H]rauwolscine from Alpha-2 adrenergic receptor of rat cortical... | 9767652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9767652 | 10.1021/jm980284m | D(2) dopamine receptor | 1 |
| 9767652 | 10.1021/jm980284m | D(1A) dopamine receptor | 1 |
| 9767652 | 10.1021/jm980284m | Adrenergic receptor alpha-1 | 1 |
| 9767652 | 10.1021/jm980284m | Adrenergic receptor alpha-2 | 1 |
Data from ChEMBL 36 via Core Engine