Assay Detail
Binding
CHEMBL643911
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Displacement of [3H]rauwolscine from Alpha-2 adrenergic receptor of rat cortical membranes
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.05 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132304 | — | — | 1 | 9.30 |
| CHEMBL134746 | — | — | 1 | 7.48 |
| CHEMBL133432 | — | — | 1 | 7.17 |
| CHEMBL134134 | — | — | 1 | 6.85 |
| CHEMBL134903 | — | — | 1 | 6.81 |
| CHEMBL132187 | — | — | 1 | 6.80 |
| CHEMBL133431 | — | — | 1 | 6.71 |
| CHEMBL336274 | — | — | 1 | 6.65 |
| CHEMBL134273 | — | — | 1 | 6.60 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132304 | — | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL134746 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL133432 | — | IC50 | = | 67.5 | nM | 7.17 |
| CHEMBL134134 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL134903 | — | IC50 | = | 154.0 | nM | 6.81 |
| CHEMBL132187 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL133431 | — | IC50 | = | 197.0 | nM | 6.71 |
| CHEMBL336274 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL134273 | — | IC50 | = | 251.0 | nM | 6.60 |
| CHEMBL1437 | NOREPINEPHRINE | IC50 | = | 750.0 | nM | 6.12 |