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Compound Detail

CHEMBL134134

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C#CCN1CCCC2Cc3ccccc3CC21

Basic Information

ChEMBL ID CHEMBL134134
Phase Preclinical
Structure Type MOL
InChI Key QBYJCHHMWPLLFC-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

225.3
MW (Da)
2.50
ALogP
1
HBA
0
HBD
3.2
PSA (Ų)
0.66
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H19N
MW 225.33
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness -0.25

Activity Summary

IC50 2 meas. best 6.85

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adrenergic receptor alpha-2
CHEMBL2093864
IC50 6.85 6.85 142.0 1
Adrenergic receptor alpha-1
CHEMBL1907610
IC50 5.89 5.89 1300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
9767652 10.1021/jm980284m D(2) dopamine receptor 1
9767652 10.1021/jm980284m D(1A) dopamine receptor 1
9767652 10.1021/jm980284m Adrenergic receptor alpha-1 1
9767652 10.1021/jm980284m Adrenergic receptor alpha-2 1

Data from ChEMBL 36 via Core Engine