Assay Detail
Binding
CHEMBL643632
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Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cortical membranes
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
N-(Iodopropenyl)-octahydrobenzo[f]- and -[g]quinolines: synthesis and adrenergic and dopaminergic activity studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.40 | 7.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336274 | — | — | 1 | 7.37 |
| CHEMBL132304 | — | — | 1 | 7.27 |
| CHEMBL134273 | — | — | 1 | 6.68 |
| CHEMBL133615 | — | — | 1 | 6.65 |
| CHEMBL336128 | — | — | 1 | 6.60 |
| CHEMBL134746 | — | — | 1 | 6.56 |
| CHEMBL336739 | — | — | 1 | 6.30 |
| CHEMBL421914 | — | — | 1 | 6.29 |
| CHEMBL134134 | — | — | 1 | 5.89 |
| CHEMBL1437 | NOREPINEPHRINE | 4.0 | 1 | 5.82 |
| CHEMBL133431 | — | — | 1 | 5.73 |
| CHEMBL133432 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336274 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL132304 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL134273 | — | IC50 | = | 209.0 | nM | 6.68 |
| CHEMBL133615 | — | IC50 | = | 225.0 | nM | 6.65 |
| CHEMBL336128 | — | IC50 | = | 253.0 | nM | 6.60 |
| CHEMBL134746 | — | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL336739 | — | IC50 | = | 497.0 | nM | 6.30 |
| CHEMBL421914 | — | IC50 | = | 508.0 | nM | 6.29 |
| CHEMBL134134 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1437 | NOREPINEPHRINE | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL133431 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL133432 | — | IC50 | = | 2200.0 | nM | 5.66 |