Compound Detail
CHEMBL336739
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Basic Information
| ChEMBL ID | CHEMBL336739 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LONFSOILWWNRLK-GDBMZVCRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
255.4
MW (Da)
2.82
ALogP
2
HBA
0
HBD
12.5
PSA (Ų)
0.75
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.71
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 CHEMBL2093864 | IC50 | 6.71 | 6.71 | 196.0 | 1 |
| Adrenergic receptor alpha-1 CHEMBL1907610 | IC50 | 6.3 | 6.3 | 497.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Adrenergic receptor alpha-2 | IC50 | = | 196.0 | nM | 6.71 | Inhibition of specific binding of [3H]rauwolscine to Alpha-2 adrenergic receptor... | 9767652 |
| Adrenergic receptor alpha-1 | IC50 | = | 497.0 | nM | 6.3 | Displacement of [3H]prazosin from Alpha-1 adrenergic receptor of rat cortical me... | 9767652 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9767652 | 10.1021/jm980284m | D(2) dopamine receptor | 1 |
| 9767652 | 10.1021/jm980284m | D(1A) dopamine receptor | 1 |
| 9767652 | 10.1021/jm980284m | Adrenergic receptor alpha-1 | 1 |
| 9767652 | 10.1021/jm980284m | Adrenergic receptor alpha-2 | 1 |
Data from ChEMBL 36 via Core Engine