Compound Detail
CHEMBL1358059
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Basic Information
| ChEMBL ID | CHEMBL1358059 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WYRVXUZELYCAMB-SNAWJCMRSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
376.4
MW (Da)
1.32
ALogP
8
HBA
0
HBD
105.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.77
IC50 1 meas. best 5.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 CHEMBL2097170 | IC50 | 5.13 | 5.13 | 7430.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.77 | 4.77 | 16962.0 | 1 |
| RNA-binding protein pos-1 CHEMBL1293304 | EC50 | 4.66 | 4.66 | 22141.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Voltage-gated N-type calcium channel alpha-1B subunit/Amyloid beta A4 precursor protein-binding family A member 1 | IC50 | = | 7430.0 | nM | 5.13 | PUBCHEM_BIOASSAY: uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance ... | - |
| Zinc finger protein mex-5 | EC50 | = | 16962.0 | nM | 4.77 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
| RNA-binding protein pos-1 | EC50 | = | 22141.0 | nM | 4.66 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Data from ChEMBL 36 via Core Engine