Compound Detail
CHEMBL136760
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Basic Information
| ChEMBL ID | CHEMBL136760 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SDADZOKIHXSRSR-OVCLIPMQSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
354.5
MW (Da)
3.50
ALogP
5
HBA
1
HBD
72.8
PSA (Ų)
0.56
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 7.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C alpha type CHEMBL299 | Ki | 7.95 | 7.95 | 11.2 | 1 |
| Unchecked CHEMBL612545 | Ki | 7.95 | 7.95 | 11.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C alpha type | Ki | = | 11.25 | nM | 7.95 | Displacement of [20-3H]-PDBU ligand from recombinant protein kinase C (baculovir... | 11728178 |
| Unchecked | Ki | = | 11.25 | nM | 7.95 | Binding affinity for protein kinase C-alpha C1a and C1b domains | 15369389 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11728178 | 10.1021/jm0103965 | No relevant target | 1 |
| 11728178 | 10.1021/jm0103965 | Protein kinase C alpha type | 1 |
| 15369389 | 10.1021/jm049723+ | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine