Compound Detail
CHEMBL1376392
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL1376392 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ATRRQBZUOKATSJ-BQYQJAHWSA-N |
4
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
248.3
MW (Da)
1.46
ALogP
3
HBA
2
HBD
81.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 6.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 CHEMBL1741194 | IC50 | 6.06 | 5.655 | 870.0 | 2 |
| Mitochondrial import inner membrane translocase subunit TIM23 CHEMBL1741180 | IC50 | 5.63 | 5.63 | 2340.0 | 1 |
| Saccharomyces cerevisiae CHEMBL361 | IC50 | 5.27 | 5.27 | 5330.0 | 1 |
| NACHT, LRR and PYD domains-containing protein 1 CHEMBL1741214 | IC50 | 5.07 | 5.07 | 8500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 870.0 | nM | 6.06 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| Mitochondrial import inner membrane translocase subunit TIM23 | IC50 | = | 2340.0 | nM | 5.63 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| Saccharomyces cerevisiae | IC50 | = | 5330.0 | nM | 5.27 | PUBCHEM_BIOASSAY: Dose Response confirmation of inhibitors of NALP1 in yeast usi... | - |
| Mitochondrial import inner membrane translocase subunit TIM10 | IC50 | = | 5670.0 | nM | 5.25 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors o... | - |
| NACHT, LRR and PYD domains-containing protein 1 | IC50 | = | 8500.0 | nM | 5.07 | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS for the identification of i... | - |
Data from ChEMBL 36 via Core Engine