Compound Detail
CHEMBL1378
THIETHYLPERAZINE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1378 |
| Name | THIETHYLPERAZINE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | XCTYLCDETUVOIP-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
2
Known Names
3
Indications
Molecular Properties
399.6
MW (Da)
5.04
ALogP
5
HBA
0
HBD
9.7
PSA (Ų)
0.63
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1961 |
| Availability | Discontinued |
| Chirality | Achiral |
Indications
Hypersensitivity Hernia, Inguinal Alzheimer Disease
ATC Classification
R06AD03
thiethylperazine
Level 1: RESPIRATORY SYSTEM
Level 2: ANTIHISTAMINES FOR SYSTEMIC USE
Activity Summary
IC50 2 meas. best 5.64
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs CHEMBL1697658 | IC50 | 5.64 | 5.64 | 2300.0 | 1 |
| Chikungunya virus CHEMBL4296563 | IC50 | 4.82 | 4.82 | 15000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Pleiotropic ABC efflux transporter of multiple drugs | IC50 | = | 2300.0 | nM | 5.64 | Inhibition of Pdr5p-mediated rhodamine 6G transport in Saccharomyces cerevisiae ... | 19188399 |
| Chikungunya virus | IC50 | = | 15000.0 | nM | 4.82 | Antiviral activity against Chikungunya virus LR2006 OPY1 infected in BHK cells m... | 28689975 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M2 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Progesterone receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 3 |
| 37468498 | 10.1038/s41467-023-40064-9 | Nuclear receptor subfamily 1 group I member 2 | 3 |
| 19188399 | 10.1128/aac.00956-08 | Pleiotropic ABC efflux transporter of multiple drugs | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Amine oxidase [flavin-containing] A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent noradrenaline transporter | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Adenosine receptor A3 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Sodium-dependent dopamine transporter | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | 5-hydroxytryptamine receptor 2A | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 28689975 | 10.1016/j.bmc.2017.06.049 | Unchecked | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Beta-1 adrenergic receptor | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| 19188399 | 10.1128/aac.00956-08 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine