Compound Detail
CHEMBL138093
SENAZODAN 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL138093 |
| Name | SENAZODAN |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XEBRQQXYWHMEQW-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
4
Publications
1
Known Names
Molecular Properties
266.3
MW (Da)
2.44
ALogP
4
HBA
2
HBD
66.4
PSA (Ų)
0.90
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
EC50 2 meas. best 4.7
IC50 2 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.44 | 6.44 | 360.0 | 1 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 CHEMBL240 | IC50 | 5.98 | 5.98 | 1047.1 | 1 |
| Cavia porcellus CHEMBL369 | EC50 | 4.7 | 4.585 | 20000.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 360.0 | nM | 6.44 | Antiplatelet activity in human platelet | 34902735 |
| Voltage-gated inwardly rectifying potassium channel KCNH2 | IC50 | = | 1047.13 | nM | 5.98 | Inhibition of human ERG | 21185626 |
| Cavia porcellus | EC50 | = | 20000.0 | nM | 4.7 | The compound was tested in vitro for chronotropic activity in isolated right atr... | 1447745 |
| Cavia porcellus | EC50 | = | 34000.0 | nM | 4.47 | In vitro inotropic activity in isolated left atria from guinea pig. | 1447745 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1447745 | 10.1021/jm00101a024 | Canis familiaris | 5 |
| 1447745 | 10.1021/jm00101a024 | Cavia porcellus | 4 |
| 21185626 | 10.1016/j.ejmech.2010.11.042 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 34902735 | 10.1016/j.ejmech.2021.114035 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine