Assay Detail
Functional
CHEMBL688554
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inotropic activity in isolated left atria from guinea pig.
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Cardiotonic agents. Synthesis and cardiovascular properties of novel 2-arylbenzimidazoles and azabenzimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 29 | 4.52 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL189 | MILRINONE | 4.0 | 1 | 5.33 |
| CHEMBL345063 | — | — | 1 | 5.00 |
| CHEMBL139298 | — | — | 1 | 4.85 |
| CHEMBL138341 | — | — | 1 | 4.82 |
| CHEMBL138163 | — | — | 1 | 4.82 |
| CHEMBL139342 | — | — | 1 | 4.80 |
| CHEMBL344921 | — | — | 1 | 4.70 |
| CHEMBL138804 | — | — | 1 | 4.62 |
| CHEMBL140356 | — | — | 1 | 4.62 |
| CHEMBL141094 | — | — | 1 | 4.58 |
| CHEMBL286020 | SULMAZOLE | 2.0 | 1 | 4.51 |
| CHEMBL1203326 | — | — | 1 | 4.47 |
| CHEMBL138093 | SENAZODAN | 2.0 | 1 | 4.47 |
| CHEMBL139403 | — | — | 1 | 4.46 |
| CHEMBL341781 | — | — | 1 | 4.43 |
| CHEMBL138114 | — | — | 1 | 4.41 |
| CHEMBL138303 | — | — | 1 | 4.37 |
| CHEMBL140647 | — | — | 1 | 4.30 |
| CHEMBL413481 | — | — | 1 | 4.30 |
| CHEMBL139626 | — | — | 1 | 4.30 |
| CHEMBL343954 | — | — | 1 | 4.30 |
| CHEMBL141621 | — | — | 1 | 4.25 |
| CHEMBL141620 | — | — | 1 | 4.24 |
| CHEMBL345089 | — | — | 1 | 4.09 |
| CHEMBL342633 | — | — | 1 | 4.06 |
| CHEMBL138157 | — | — | 1 | - |
| CHEMBL138652 | — | — | 1 | - |
| CHEMBL138430 | — | — | 1 | - |
| CHEMBL138315 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL189 | MILRINONE | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL345063 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL139298 | — | EC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL138341 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL138163 | — | EC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL139342 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL344921 | — | EC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL138804 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL140356 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL141094 | — | EC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL286020 | SULMAZOLE | EC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1203326 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL138093 | SENAZODAN | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL139403 | — | EC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL341781 | — | EC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL138114 | — | EC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL138303 | — | EC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL140647 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL413481 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL139626 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL343954 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL141621 | — | EC50 | = | 56000.0 | nM | 4.25 |
| CHEMBL141620 | — | EC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL345089 | — | EC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL342633 | — | EC50 | = | 88000.0 | nM | 4.06 |
| CHEMBL138157 | — | EC50 | = | 200000.0 | nM | - |
| CHEMBL138652 | — | EC50 | = | 150000.0 | nM | - |
| CHEMBL138430 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL138315 | — | EC50 | = | 500000.0 | nM | - |