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Compound Detail

CHEMBL344921

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Cc1cn(-c2cc3[nH]c(-c4ccncc4)nc3cc2Cl)cn1

Basic Information

ChEMBL ID CHEMBL344921
Phase Preclinical
Structure Type MOL
InChI Key DOQSXYXXRHPKLI-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

309.8
MW (Da)
3.77
ALogP
4
HBA
1
HBD
59.4
PSA (Ų)
0.61
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H12ClN5
MW 309.76
Aromatic Rings 4
Heavy Atoms 22
NP-Likeness -1.49

Activity Summary

EC50 1 meas. best 4.7

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cavia porcellus
CHEMBL369
EC50 4.7 4.7 20000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Cavia porcellus EC50 = 20000.0 nM 4.7 In vitro inotropic activity in isolated left atria from guinea pig. 1447745

Literature References

PubMed DOI Target Context # Activities
1447745 10.1021/jm00101a024 Canis familiaris 4
1447745 10.1021/jm00101a024 Cavia porcellus 2

Data from ChEMBL 36 via Core Engine