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Compound Detail

CHEMBL139610

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O=C(OC1CCNC1)C(O)(c1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL139610
Phase Preclinical
Structure Type MOL
InChI Key CECGGRRIGNRBDE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

297.4
MW (Da)
1.83
ALogP
4
HBA
2
HBD
58.6
PSA (Ų)
0.85
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H19NO3
MW 297.35
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness 0.09

Activity Summary

Ki 1 meas. best 8.63

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 8.63 8.63 2.3 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11087580 10.1021/jm000305o Muscarinic acetylcholine receptor 1
11087580 10.1021/jm000305o No relevant target 1

Data from ChEMBL 36 via Core Engine