Assay Detail
Binding
CHEMBL741872
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In vitro for binding affinity for muscarinic acetylcholine receptors in homogenized rat brain in the presence of [3H]scopolamine.
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis, (18)F-labeling, and biological evaluation of piperidyl and pyrrolidyl benzilates as in vivo ligands for muscarinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 8.41 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL142136 | — | — | 1 | 10.30 |
| CHEMBL143228 | — | — | 1 | 10.15 |
| CHEMBL141269 | — | — | 1 | 9.80 |
| CHEMBL343764 | — | — | 1 | 9.39 |
| CHEMBL342839 | — | — | 1 | 9.18 |
| CHEMBL142084 | — | — | 1 | 9.14 |
| CHEMBL141559 | — | — | 1 | 8.74 |
| CHEMBL139610 | — | — | 1 | 8.63 |
| CHEMBL140277 | — | — | 1 | 8.59 |
| CHEMBL141842 | — | — | 1 | 8.57 |
| CHEMBL341731 | — | — | 1 | 8.37 |
| CHEMBL141097 | — | — | 1 | 8.34 |
| CHEMBL335339 | — | — | 1 | 8.29 |
| CHEMBL142026 | — | — | 1 | 8.21 |
| CHEMBL140576 | — | — | 1 | 8.07 |
| CHEMBL140993 | — | — | 1 | 8.06 |
| CHEMBL421933 | — | — | 1 | 7.78 |
| CHEMBL141174 | — | — | 1 | 7.68 |
| CHEMBL141701 | — | — | 1 | 7.59 |
| CHEMBL337773 | — | — | 1 | 7.51 |
| CHEMBL140935 | — | — | 1 | 7.37 |
| CHEMBL140992 | — | — | 1 | 6.88 |
| CHEMBL141026 | — | — | 1 | 6.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL142136 | — | Ki | = | 0.05 | nM | 10.30 |
| CHEMBL143228 | — | Ki | = | 0.07 | nM | 10.15 |
| CHEMBL141269 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL343764 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL342839 | — | Ki | = | 0.66 | nM | 9.18 |
| CHEMBL142084 | — | Ki | = | 0.72 | nM | 9.14 |
| CHEMBL141559 | — | Ki | = | 1.83 | nM | 8.74 |
| CHEMBL139610 | — | Ki | = | 2.34 | nM | 8.63 |
| CHEMBL140277 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL141842 | — | Ki | = | 2.67 | nM | 8.57 |
| CHEMBL341731 | — | Ki | = | 4.26 | nM | 8.37 |
| CHEMBL141097 | — | Ki | = | 4.57 | nM | 8.34 |
| CHEMBL335339 | — | Ki | = | 5.15 | nM | 8.29 |
| CHEMBL142026 | — | Ki | = | 6.23 | nM | 8.21 |
| CHEMBL140576 | — | Ki | = | 8.43 | nM | 8.07 |
| CHEMBL140993 | — | Ki | = | 8.72 | nM | 8.06 |
| CHEMBL421933 | — | Ki | = | 16.7 | nM | 7.78 |
| CHEMBL141174 | — | Ki | = | 20.9 | nM | 7.68 |
| CHEMBL141701 | — | Ki | = | 25.6 | nM | 7.59 |
| CHEMBL337773 | — | Ki | = | 30.6 | nM | 7.51 |
| CHEMBL140935 | — | Ki | = | 42.6 | nM | 7.37 |
| CHEMBL140992 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL141026 | — | Ki | = | 146.0 | nM | 6.84 |