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Compound Detail

CHEMBL421933

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O=C(OC1CCN(Cc2ccc([N+](=O)[O-])cc2)CC1)C(O)(c1ccccc1)c1ccccc1

Basic Information

ChEMBL ID CHEMBL421933
Phase Preclinical
Structure Type MOL
InChI Key OSRRPPAVDDEACA-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

446.5
MW (Da)
4.04
ALogP
6
HBA
1
HBD
92.9
PSA (Ų)
0.33
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H26N2O5
MW 446.50
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.81

Activity Summary

Ki 1 meas. best 7.78

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 7.78 7.78 16.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11087580 10.1021/jm000305o Muscarinic acetylcholine receptor 1
11087580 10.1021/jm000305o No relevant target 1

Data from ChEMBL 36 via Core Engine