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Compound Detail

CHEMBL139887

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CN1CCC=C(c2nsnc2OCCOCCOCCOCCOCCOCCOc2nsnc2C2=CCCN(C)C2)C1

Basic Information

ChEMBL ID CHEMBL139887
Phase Preclinical
Structure Type MOL
InChI Key ZFPDBZINGWXASE-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

640.8
MW (Da)
2.37
ALogP
15
HBA
0
HBD
122.7
PSA (Ų)
0.18
QED
2
Ro5 Violations
22
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C28H44N6O7S2
MW 640.83
Aromatic Rings 2
Heavy Atoms 43
NP-Likeness -0.38

Activity Summary

Ki 1 meas. best 8.72

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.72 8.72 1.9 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11741475 10.1021/jm0102405 Muscarinic acetylcholine receptor M1 2

Data from ChEMBL 36 via Core Engine