Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL140789

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
CN1CCC=C(c2nsnc2SCCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1

Basic Information

ChEMBL ID CHEMBL140789
Phase Preclinical
Structure Type MOL
InChI Key SACCLAHUORGRHA-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

536.9
MW (Da)
6.05
ALogP
10
HBA
0
HBD
58.0
PSA (Ų)
0.23
QED
2
Ro5 Violations
13
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H36N6S4
MW 536.86
Aromatic Rings 2
Heavy Atoms 34
NP-Likeness -0.36

Activity Summary

EC50 1 meas. best 6.04
Ki 1 meas. best 8.3

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.3 8.3 5.0 1
Muscarinic acetylcholine receptor M1
CHEMBL216
EC50 6.04 6.04 920.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11741475 10.1021/jm0102405 Muscarinic acetylcholine receptor M1 3

Data from ChEMBL 36 via Core Engine