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Compound Detail

CHEMBL140985

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CN1CCC=C(c2nsnc2SCCCCCCCSc2nsnc2C2=CCCN(C)C2)C1

Basic Information

ChEMBL ID CHEMBL140985
Phase Preclinical
Structure Type MOL
InChI Key BOAPENYDEADGEH-UHFFFAOYSA-N
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

522.8
MW (Da)
5.66
ALogP
10
HBA
0
HBD
58.0
PSA (Ų)
0.26
QED
2
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H34N6S4
MW 522.84
Aromatic Rings 2
Heavy Atoms 33
NP-Likeness -0.38

Activity Summary

EC50 1 meas. best 6.75
Ki 1 meas. best 8.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 8.12 8.12 7.6 1
Muscarinic acetylcholine receptor M1
CHEMBL216
EC50 6.75 6.75 180.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
11741475 10.1021/jm0102405 Muscarinic acetylcholine receptor M1 3

Data from ChEMBL 36 via Core Engine