Compound Detail
CHEMBL141450
SAVIPRAZOLE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL141450 |
| Name | SAVIPRAZOLE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | ARFGGIRJBPTBPP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
7
Publications
2
Known Names
Molecular Properties
461.4
MW (Da)
4.54
ALogP
5
HBA
1
HBD
73.9
PSA (Ų)
0.41
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 1 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Oryctolagus cuniculus CHEMBL374 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 8.0 | hr | - |
| T1/2 | 1.4 | hr | - |
| T1/2 | 0.05 | hr | - |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Oryctolagus cuniculus | IC50 | = | 1300.0 | nM | 5.89 | In vitro inhibition of 14C amino-pyrine uptake was determined in isolated rabbit... | 1310742 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1310742 | 10.1021/jm00081a004 | No relevant target | 4 |
| 1310742 | 10.1021/jm00081a004 | Canis familiaris | 2 |
| 1310742 | 10.1021/jm00081a004 | Potassium-transporting ATPase alpha chain 1 | 1 |
| 1310742 | 10.1021/jm00081a004 | Oryctolagus cuniculus | 1 |
| 1310742 | 10.1021/jm00081a004 | Potassium-transporting ATPase | 1 |
| 1310742 | 10.1021/jm00081a004 | Rattus norvegicus | 1 |
| 1310742 | 10.1021/jm00081a004 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine