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Assay Detail

CHEMBL771608

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of 14C amino-pyrine uptake was determined in isolated rabbit gastric glands after dbcAMP stimulation
ChEMBL ↗
76
Total Activities
76
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Oryctolagus cuniculus
Tissue Stomach
Confidence 1 — Organism
Curated By Expert

Target

Oryctolagus cuniculus (CHEMBL374) ↗
Type ORGANISM
Organism Oryctolagus cuniculus

Publication

2-[(2-pyridylmethyl)sulfinyl]-1H-thieno[3,4-d]imidazoles. A novel class of gastric H+/K(+)-ATPase inhibitors.
Weidmann K, Herling AW, Lang HJ, Scheunemann KH, Rippel R, Nimmesgern H, Scholl T, Bickel M, Metzger H.
J Med Chem (1992) 35 : 438 -450
PubMed 1310742 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 76 5.56 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL142091 — — 1 6.52
CHEMBL140923 — — 1 6.52
CHEMBL142140 — — 1 6.40
CHEMBL140772 — — 1 6.30
CHEMBL139135 — — 1 6.30
CHEMBL137943 — — 1 6.30
CHEMBL434456 — — 1 6.30
CHEMBL336232 — — 1 6.30
CHEMBL138555 — — 1 6.22
CHEMBL141735 — — 1 6.22
CHEMBL139628 — — 1 6.16
CHEMBL141355 — — 1 6.10
CHEMBL140657 — — 1 6.00
CHEMBL138559 — — 1 6.00
CHEMBL138021 — — 1 6.00
CHEMBL344655 — — 1 6.00
CHEMBL138701 — — 1 6.00
CHEMBL140714 — — 1 6.00
CHEMBL139433 — — 1 6.00
CHEMBL138196 — — 1 6.00
CHEMBL138307 — — 1 6.00
CHEMBL345036 — — 1 6.00
CHEMBL344250 — — 1 5.96
CHEMBL139138 — — 1 5.96
CHEMBL141264 — — 1 5.96
CHEMBL141450 SAVIPRAZOLE 2.0 1 5.89
CHEMBL344406 — — 1 5.70
CHEMBL138702 — — 1 5.70
CHEMBL138444 — — 1 5.70
CHEMBL343307 — — 1 5.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL142091 — IC50 = 300.0 nM 6.52
CHEMBL140923 — IC50 = 300.0 nM 6.52
CHEMBL142140 — IC50 = 400.0 nM 6.40
CHEMBL140772 — IC50 = 500.0 nM 6.30
CHEMBL139135 — IC50 = 500.0 nM 6.30
CHEMBL137943 — IC50 = 500.0 nM 6.30
CHEMBL434456 — IC50 = 500.0 nM 6.30
CHEMBL336232 — IC50 = 500.0 nM 6.30
CHEMBL138555 — IC50 = 600.0 nM 6.22
CHEMBL141735 — IC50 = 600.0 nM 6.22
CHEMBL139628 — IC50 = 700.0 nM 6.16
CHEMBL141355 — IC50 = 800.0 nM 6.10
CHEMBL138196 — IC50 = 1000.0 nM 6.00
CHEMBL140657 — IC50 = 1000.0 nM 6.00
CHEMBL138559 — IC50 = 1000.0 nM 6.00
CHEMBL138021 — IC50 = 1000.0 nM 6.00
CHEMBL138701 — IC50 = 1000.0 nM 6.00
CHEMBL140714 — IC50 = 1000.0 nM 6.00
CHEMBL139433 — IC50 = 1000.0 nM 6.00
CHEMBL344655 — IC50 = 1000.0 nM 6.00
CHEMBL138307 — IC50 = 1000.0 nM 6.00
CHEMBL345036 — IC50 = 1000.0 nM 6.00
CHEMBL344250 — IC50 = 1100.0 nM 5.96
CHEMBL139138 — IC50 = 1100.0 nM 5.96
CHEMBL141264 — IC50 = 1100.0 nM 5.96
CHEMBL141450 SAVIPRAZOLE IC50 = 1300.0 nM 5.89
CHEMBL138702 — IC50 = 2000.0 nM 5.70
CHEMBL138444 — IC50 = 2000.0 nM 5.70
CHEMBL343307 — IC50 = 2000.0 nM 5.70
CHEMBL344406 — IC50 = 2000.0 nM 5.70
CHEMBL142035 — IC50 = 2200.0 nM 5.66
CHEMBL140836 — IC50 = 2300.0 nM 5.64
CHEMBL139225 — IC50 = 2500.0 nM 5.60
CHEMBL138668 — IC50 = 2500.0 nM 5.60
CHEMBL341550 — IC50 = 3000.0 nM 5.52
CHEMBL139408 — IC50 = 3000.0 nM 5.52
CHEMBL138554 — IC50 = 3000.0 nM 5.52
CHEMBL140688 — IC50 = 3000.0 nM 5.52
CHEMBL342856 — IC50 = 3000.0 nM 5.52
CHEMBL140546 — IC50 = 3000.0 nM 5.52
CHEMBL138420 — IC50 = 3600.0 nM 5.44
CHEMBL140604 — IC50 = 3700.0 nM 5.43
CHEMBL140658 — IC50 = 4000.0 nM 5.40
CHEMBL140889 — IC50 = 4200.0 nM 5.38
CHEMBL138606 — IC50 = 6000.0 nM 5.22
CHEMBL342169 — IC50 = 6000.0 nM 5.22
CHEMBL139018 — IC50 = 9000.0 nM 5.05
CHEMBL138563 — IC50 = 10000.0 nM 5.00
CHEMBL138748 — IC50 = 12000.0 nM 4.92
CHEMBL141978 — IC50 = 15000.0 nM 4.82