Compound Detail
CHEMBL1420733
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Basic Information
| ChEMBL ID | CHEMBL1420733 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HLPCWKJOJSOZPX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
328.4
MW (Da)
2.72
ALogP
7
HBA
3
HBD
103.5
PSA (Ų)
0.38
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Signal transducer and activator of transcription 1-alpha/beta CHEMBL6101 | IC50 | 5.03 | 5.03 | 9385.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.48 | 4.48 | 33135.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Signal transducer and activator of transcription 1-alpha/beta | IC50 | = | 9385.0 | nM | 5.03 | PUBCHEM_BIOASSAY: Dose response cell-based assay to measure STAT1 inhibition. (C... | - |
| Unchecked | IC50 | = | 33135.0 | nM | 4.48 | PUBCHEM_BIOASSAY: Dose response confirmation of uHTS hits for small molecule mod... | - |
Data from ChEMBL 36 via Core Engine