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Compound Detail

CHEMBL1424807

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Clc1cccc(N2CCNCC2)c1Cl

Basic Information

ChEMBL ID CHEMBL1424807
Phase Preclinical
Structure Type MOL
InChI Key UDQMXYJSNNCRAS-UHFFFAOYSA-N
3
Targets
5
Activities
1
Assay Types
0
PK Parameters
11
Publications
0
Known Names

Molecular Properties

231.1
MW (Da)
2.40
ALogP
2
HBA
1
HBD
15.3
PSA (Ų)
0.80
QED
0
Ro5 Violations
1
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H12Cl2N2
MW 231.13
Aromatic Rings 1
Heavy Atoms 14
NP-Likeness -1.34

Activity Summary

Ki 5 meas. best 6.97

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.97 6.97 107.2 1
D(2) dopamine receptor
CHEMBL217
Ki 6.86 6.2467 137.3 3
D(3) dopamine receptor
CHEMBL234
Ki 6.71 6.71 197.4 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
22632094 10.1021/jm300482h D(3) dopamine receptor 2
22632094 10.1021/jm300482h D(2) dopamine receptor 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M4 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M3 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M2 2
23517028 10.1021/jm400140q Muscarinic acetylcholine receptor M1 2
24827597 10.1021/jm500457x D(2) dopamine receptor 2
22809299 10.1021/jm301017v D(2) dopamine receptor 1
22809299 10.1021/jm301017v D(3) dopamine receptor 1
22632094 10.1021/jm300482h Unchecked 1
23517028 10.1021/jm400140q Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine