Compound Detail
CHEMBL143453
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
CC(C)[C@@H]1Nc2c3c(cc4[nH]cc(c24)C[C@@H](CO)NC1=O)C(C)(C)CCC3(C)C
Basic Information
| ChEMBL ID | CHEMBL143453 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HHLKZSJXDAZIGG-YWZLYKJASA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
397.6
MW (Da)
3.99
ALogP
3
HBA
4
HBD
77.2
PSA (Ų)
0.62
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.4
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C, PKC; classical/novel CHEMBL2096620 | IC50 | 6.4 | 6.4 | 400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C, PKC; classical/novel | IC50 | = | 400.0 | nM | 6.4 | Binding to PKC in 3[H]-PBDU assay | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(00)80169-9 | Protein kinase C, PKC; classical/novel | 1 |
Data from ChEMBL 36 via Core Engine