Compound Detail
CHEMBL143589
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL143589 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XAUVMEDLJUGOBV-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
262.4
MW (Da)
1.29
ALogP
3
HBA
2
HBD
72.2
PSA (Ų)
0.73
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 6.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Aspartyl aminopeptidase CHEMBL2761 | Ki | 6.0 | 6.0 | 1000.0 | 1 |
| Aminopeptidase B CHEMBL2432 | Ki | 5.82 | 5.82 | 1500.0 | 1 |
| Aminopeptidase N CHEMBL1907 | Ki | 5.6 | 5.6 | 2500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Aspartyl aminopeptidase | Ki | = | 1000.0 | nM | 6.0 | Compound was tested for binding affinity towards cytosolic aminopeptidase | 1738140 |
| Aminopeptidase B | Ki | = | 1500.0 | nM | 5.82 | Compound was tested for binding affinity towards arginyl aminopeptidase | 1738140 |
| Aminopeptidase N | Ki | = | 2500.0 | nM | 5.6 | Compound was tested for binding affinity towards microsomal aminopeptidase | 1738140 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1738140 | 10.1021/jm00081a005 | Aspartyl aminopeptidase | 1 |
| 1738140 | 10.1021/jm00081a005 | Aminopeptidase N | 1 |
| 1738140 | 10.1021/jm00081a005 | Aminopeptidase B | 1 |
Data from ChEMBL 36 via Core Engine