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Compound Detail

CHEMBL1436860

DIMETHYL GAMBOGATE
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COC(=O)/C(C)=C\CC12OC(C)(C)C3CC(C=C4C(=O)c5c(OC)c6c(c(CC=C(C)C)c5OC431)OC(C)(CCC=C(C)C)C=C6)C2=O

Basic Information

ChEMBL ID CHEMBL1436860
Name DIMETHYL GAMBOGATE
Phase Preclinical
Structure Type MOL
InChI Key LFSCNWNADRUBLS-IWIPYMOSSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

656.8
MW (Da)
7.63
ALogP
8
HBA
0
HBD
97.4
PSA (Ų)
0.15
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C40H48O8
MW 656.82
Aromatic Rings 1
Heavy Atoms 48
NP-Likeness 3.32

Activity Summary

IC50 2 meas. best 5.64
Ki 2 meas. best 5.9

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 5.9 5.9 1260.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.64 5.64 2290.9 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.41 5.41 3940.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.29 5.29 5128.6 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3

Data from ChEMBL 36 via Core Engine