Compound Detail
CHEMBL1443577
SULFACHLORPYRIDAZINE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL1443577 |
| Name | SULFACHLORPYRIDAZINE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | XOXHILFPRYWFOD-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
7
Known Names
Molecular Properties
284.7
MW (Da)
1.51
ALogP
5
HBA
2
HBD
98.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Activity Summary
IC50 3 meas. best 4.49
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| No relevant target CHEMBL2362975 | IC50 | 4.49 | 4.49 | 32646.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.19 | 4.19 | 64050.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| No relevant target | IC50 | = | 32646.0 | nM | 4.49 | PubChem BioAssay. Counterscreen for inhibitors of RecBCD: Absorbance-based cell-... | - |
| Unchecked | IC50 | = | 64210.0 | nM | 4.19 | PUBCHEM_BIOASSAY: A screen for inhibitors of the PhoP region in Salmonella Typhi... | - |
| Unchecked | IC50 | = | 64050.0 | nM | 4.19 | PubChem BioAssay. Absorbance-based bacterial cell-based high throughput dose res... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19064898 | 10.1128/aac.00652-07 | NON-PROTEIN TARGET | 15 |
| 19064898 | 10.1128/aac.00652-07 | Acinetobacter lwoffii | 6 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 19064898 | 10.1128/aac.00652-07 | Acinetobacter calcoaceticus | 2 |
| 19064898 | 10.1128/aac.00652-07 | Acinetobacter baumannii | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
| - | 10.1101/2020.04.21.054387 | SARS-CoV-2 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.1101/2020.04.03.023846 | SARS-CoV-2 | 1 |
| 22961681 | 10.1124/dmd.112.047068 | Bile salt export pump | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B1 | 1 |
| 23571415 | 10.1124/mol.112.084152 | Solute carrier organic anion transporter family member 1B3 | 1 |
| 19064898 | 10.1128/aac.00652-07 | Lysinibacillus sphaericus | 1 |
| 19064898 | 10.1128/aac.00652-07 | Pseudomonas putida | 1 |
| 19064898 | 10.1128/aac.00652-07 | Providencia stuartii | 1 |
| 19064898 | 10.1128/aac.00652-07 | Enterococcus hirae | 1 |
| 19064898 | 10.1128/aac.00652-07 | Shigella flexneri | 1 |
| 19064898 | 10.1128/aac.00652-07 | Pseudomonas fluorescens | 1 |
Data from ChEMBL 36 via Core Engine