Compound Detail
CHEMBL144694
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL144694 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MFLFGBFDXCPCBG-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
351.2
MW (Da)
4.77
ALogP
2
HBA
0
HBD
32.7
PSA (Ų)
0.77
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Progesterone receptor CHEMBL208 | IC50 | 7.32 | 6.96 | 48.2 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Progesterone receptor | IC50 | = | 48.2 | nM | 7.32 | Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells ... | 8523400 |
| Progesterone receptor | IC50 | = | 250.0 | nM | 6.6 | Binding affinity towards human progesterone receptor | 8523399 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8523400 | 10.1021/jm00025a004 | Progesterone receptor | 1 |
| 8523399 | 10.1021/jm00025a003 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine