Assay Detail
Binding
CHEMBL768145
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Binding affinity against Progesterone receptor in human TE85 osteosarcoma cells was determined using (Z)-[125I]-17-alpha-(2-iodovinyl)-19-nor-testosterone as radioligand
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Nonsteroidal progesterone receptor ligands. 2. High-affinity ligands with selectivity for bone cell progesterone receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 7.09 | 8.49 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1162 | NORETHINDRONE | 4.0 | 1 | 8.49 |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | 7.77 |
| CHEMBL145224 | — | — | 1 | 7.76 |
| CHEMBL144680 | — | — | 1 | 7.62 |
| CHEMBL262171 | — | — | 1 | 7.42 |
| CHEMBL144694 | — | — | 1 | 7.32 |
| CHEMBL145544 | — | — | 1 | 7.21 |
| CHEMBL357848 | — | — | 1 | 7.15 |
| CHEMBL356741 | — | — | 1 | 7.12 |
| CHEMBL144068 | — | — | 1 | 7.08 |
| CHEMBL148070 | — | — | 1 | 7.01 |
| CHEMBL144321 | — | — | 1 | 6.77 |
| CHEMBL144815 | — | — | 1 | 6.57 |
| CHEMBL144345 | — | — | 1 | 6.38 |
| CHEMBL144803 | — | — | 1 | 6.29 |
| CHEMBL145346 | — | — | 1 | 6.28 |
| CHEMBL359228 | — | — | 1 | 6.24 |
| CHEMBL144039 | — | — | 1 | - |
| CHEMBL144180 | — | — | 1 | - |
| CHEMBL145254 | — | — | 1 | - |
| CHEMBL343409 | — | — | 1 | - |
| CHEMBL342508 | — | — | 1 | - |
| CHEMBL144038 | — | — | 1 | - |
| CHEMBL358274 | — | — | 1 | - |
| CHEMBL144289 | — | — | 1 | - |
| CHEMBL359431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1162 | NORETHINDRONE | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL103 | PROGESTERONE | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL145224 | — | IC50 | = | 17.5 | nM | 7.76 |
| CHEMBL144680 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL262171 | — | IC50 | = | 38.2 | nM | 7.42 |
| CHEMBL144694 | — | IC50 | = | 48.2 | nM | 7.32 |
| CHEMBL145544 | — | IC50 | = | 62.4 | nM | 7.21 |
| CHEMBL357848 | — | IC50 | = | 70.6 | nM | 7.15 |
| CHEMBL356741 | — | IC50 | = | 75.3 | nM | 7.12 |
| CHEMBL144068 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL148070 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL144321 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL144815 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL144345 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL144803 | — | IC50 | = | 515.0 | nM | 6.29 |
| CHEMBL145346 | — | IC50 | = | 521.0 | nM | 6.28 |
| CHEMBL359228 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL144039 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL144180 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL145254 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL343409 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL342508 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL144038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL358274 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL144289 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL359431 | — | IC50 | > | 1000.0 | nM | - |