Compound Detail
CHEMBL1449676
ORNIDAZOLE 🧪 Phase III
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🧪 Phase III
Basic Information
| ChEMBL ID | CHEMBL1449676 |
| Name | ORNIDAZOLE |
| Phase | Phase III |
| Structure Type | MOL |
| InChI Key | IPWKIXLWTCNBKN-UHFFFAOYSA-N |
| Therapeutic | ✓ Yes |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
7
Known Names
4
Indications
1
Mechanisms
Molecular Properties
219.6
MW (Da)
0.70
ALogP
5
HBA
1
HBD
81.2
PSA (Ų)
0.46
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Produces reactive intermediates | - | - | ✓ | ✓ |
Indications
Amebiasis Bacterial Infections Colonic Neoplasms Rectal Neoplasms
ATC Classification
G01AF06
ornidazole
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
J01XD03
ornidazole
Level 1: ANTIINFECTIVES FOR SYSTEMIC USE
Level 2: ANTIBACTERIALS FOR SYSTEMIC USE
P01AB03
ornidazole
Level 1: ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
Level 2: ANTIPROTOZOALS
Activity Summary
IC50 2 meas. best 4.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense CHEMBL612348 | IC50 | 4.59 | 4.59 | 25930.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Trypanosoma brucei rhodesiense | IC50 | = | 25930.0 | nM | 4.59 | DNDI: HAT in Vitro, 72 hour | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15646539 | 10.1016/s0399-8320(04)95062-2 | Unchecked | 11 |
| 3959031 | 10.1021/jm00154a021 | Rattus norvegicus | 10 |
| 15646539 | 10.1016/s0399-8320(04)95062-2 | NON-PROTEIN TARGET | 8 |
| 3806622 | 10.1021/jm00385a027 | Rattus norvegicus | 6 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Alpha-1A adrenergic receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Muscarinic acetylcholine receptor M1 | 2 |
| - | 10.6019/CHEMBL3392926 | Leishmania donovani | 2 |
| - | 10.6019/CHEMBL3392926 | NON-PROTEIN TARGET | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Thromboxane A2 receptor | 2 |
| 37468498 | 10.1038/s41467-023-40064-9 | Prostaglandin G/H synthase 1 | 2 |
| - | 10.6019/CHEMBL3392926 | Trypanosoma cruzi | 1 |
| 23956101 | 10.1093/toxsci/kft176 | Bile salt export pump | 1 |
| 23956101 | 10.1093/toxsci/kft176 | ATP-binding cassette sub-family C member 2 | 1 |
| 22902032 | 10.1016/j.bmc.2012.04.045 | Trichophyton tonsurans | 1 |
| 3959031 | 10.1021/jm00154a021 | No relevant target | 1 |
| 28463485 | 10.1021/acs.jmedchem.7b00143 | Bacteroides fragilis | 1 |
| 38318365 | 10.1016/j.isci.2024.108907 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 | 1 |
Data from ChEMBL 36 via Core Engine