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Compound Detail

CHEMBL1456870

GARCINOLIC ACID
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CC(C)=CCCC1(C)C=Cc2c(O)c3c(c(CC=C(C)C)c2O1)OC12C(=CCCC1C(C)(C)O[C@@]2(C/C=C(\C)C(=O)O)C(=O)O)C3=O

Basic Information

ChEMBL ID CHEMBL1456870
Name GARCINOLIC ACID
Phase Preclinical
Structure Type MOL
InChI Key VDSCKSOYNLTQSY-VGJPRPLGSA-N
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

646.8
MW (Da)
7.52
ALogP
7
HBA
3
HBD
139.6
PSA (Ų)
0.18
QED
2
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C38H46O9
MW 646.78
Aromatic Rings 1
Heavy Atoms 47
NP-Likeness 3.06

Activity Summary

IC50 2 meas. best 5.93
Ki 2 meas. best 6.19

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
Ki 6.19 6.19 650.0 1
Solute carrier organic anion transporter family member 1B1
CHEMBL1697668
IC50 5.93 5.93 1174.9 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
Ki 5.76 5.76 1730.0 1
Solute carrier organic anion transporter family member 1B3
CHEMBL1743121
IC50 5.65 5.65 2238.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B3 3
23571415 10.1124/mol.112.084152 Solute carrier organic anion transporter family member 1B1 3
30852084 10.1016/j.bmcl.2019.02.028 GroEL/GroES 2

Data from ChEMBL 36 via Core Engine