Compound Detail
CHEMBL1456904
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Basic Information
| ChEMBL ID | CHEMBL1456904 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZMXVWFFEPNMQNW-UHFFFAOYSA-N |
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
3.74
ALogP
4
HBA
0
HBD
42.3
PSA (Ų)
0.53
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.3
EC50 1 meas. best 4.59
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 CHEMBL1293302 | IC50 | 5.3 | 5.3 | 4963.0 | 1 |
| Protein Rev CHEMBL1293282 | IC50 | 4.85 | 4.85 | 14250.0 | 1 |
| Zinc finger protein mex-5 CHEMBL1293319 | EC50 | 4.59 | 4.59 | 25949.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Female germline-specific tumor suppressor gld-1 | IC50 | = | 4963.0 | nM | 5.3 | PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput do... | - |
| Protein Rev | IC50 | = | 14250.0 | nM | 4.85 | PUBCHEM_BIOASSAY: Counterscreen for inhibitors of gld-1: Fluorescence polarizati... | - |
| Zinc finger protein mex-5 | EC50 | = | 25949.0 | nM | 4.59 | PUBCHEM_BIOASSAY: Fluorescent Polarization Homogeneous Dose Response HTS to Iden... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24785979 | 10.1021/jm500300r | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine