Compound Detail

CHEMBL146408

AMIDEPHRINE MESYLATE

🧪 Phase II

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🧪 Phase II

CNCC(O)c1cccc(NS(C)(=O)=O)c1

ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID	CHEMBL146408
Name	AMIDEPHRINE MESYLATE
Phase	Phase II
Structure Type	MOL
InChI Key	ZHOWHMXTJFZXRB-UHFFFAOYSA-N

Known Names

5190 Amidefrine Amidefrine mesilate Amidephrine Amidephrine mesilate Amidephrine mesylate Amidephrine methanesulfonate Fentrinol Mesilate d'amidefrine Mesilato de amidefrina MJ-1996 MJ-5190

Targets

Activities

Assay Types

PK Parameters

Publications

Known Names

Molecular Properties

244.3

MW (Da)

0.31

ALogP

HBA

HBD

78.4

PSA (Å²)

0.70

QED

Ro5 Violations

Rot. Bonds

Drug Information

Molecule Type	Small molecule
Chirality	Racemic

USAN Year

1965

Extended Properties

Molecular Formula	C10H16N2O3S
MW	244.32
Aromatic Rings	1
Heavy Atoms	16
NP-Likeness	-0.70

Activity Summary

IC50 2 meas. best 4.72

Target Activity Profile

Target	Type	Best pChEMBL	Mean pChEMBL	Best (nM)	# Data
Adrenergic receptor alpha-2 CHEMBL2093864	IC50	4.72	4.72	19000.0	1
Adrenergic receptor alpha-1 CHEMBL1907610	IC50	4.4	4.4	40000.0	1

Activity Data Samples

Top measurements by pChEMBL value

Target	Type	Rel.	Value	Units	pChEMBL	Assay	PubMed
Adrenergic receptor alpha-2	IC50	=	19000.0	nM	4.72	50% inhibition of specific [3H]clonidine binding (0.4 nM) to Alpha-2 adrenergic ...	6142954
Adrenergic receptor alpha-1	IC50	=	40000.0	nM	4.4	Binding affinity against alpha-1 adrenergic receptor is the ability to inhibit t...	6142954

Literature References

PubMed	DOI	Target Context	# Activities
-	10.6019/CHEMBL4651402	SARS-CoV-2	2
6142954	10.1021/jm00370a011	Oryctolagus cuniculus	1
6142954	10.1021/jm00370a011	Adrenergic receptor alpha-1	1
6142954	10.1021/jm00370a011	Adrenergic receptor alpha-2	1
31486	10.1021/jm00207a015	Unchecked	1

Data from ChEMBL 36 via Core Engine