Compound Detail
CHEMBL146624
MITOGLITAZONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL146624 |
| Name | MITOGLITAZONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | IRNJSRAGRIZIHD-UHFFFAOYSA-N |
5
Targets
6
Activities
2
Assay Types
1
PK Parameters
11
Publications
7
Known Names
2
Indications
Molecular Properties
370.4
MW (Da)
2.80
ALogP
6
HBA
1
HBD
85.4
PSA (Ų)
0.75
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Racemic |
Indications
Alzheimer Disease Diabetes Mellitus, Type 2
Activity Summary
IC50 5 meas. best 5.92
EC50 1 meas. best 6.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | EC50 | 6.18 | 6.18 | 657.0 | 1 |
| Mitochondrial pyruvate carrier 2 CHEMBL4295686 | IC50 | 5.92 | 5.92 | 1200.0 | 1 |
| Cytochrome P450 2C9 CHEMBL3397 | IC50 | 4.66 | 4.66 | 22000.0 | 1 |
| Peroxisome proliferator-activated receptor gamma CHEMBL235 | IC50 | 4.65 | 4.65 | 22300.0 | 1 |
| Cytochrome P450 2C8 CHEMBL3721 | IC50 | 4.58 | 4.58 | 26000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 4.58 | 4.58 | 26600.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| F | 73.0 | % | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | EC50 | = | 657.0 | nM | 6.18 | Transactivation of GAL4-DBD fused human PPARgamma ligand binding domain expresse... | 30429097 |
| Mitochondrial pyruvate carrier 2 | IC50 | = | 1200.0 | nM | 5.92 | Displacement of photoprobe from MPC2 (unknown origin) | 30429097 |
| Cytochrome P450 2C9 | IC50 | = | 22000.0 | nM | 4.66 | Inhibition of CYP2C9 (unknown origin) | 30429097 |
| Peroxisome proliferator-activated receptor gamma | IC50 | = | 22300.0 | nM | 4.65 | Competitive displacement of fluorescently labelled PPAR tracer ligand from GST-t... | 30429097 |
| Cytochrome P450 2C8 | IC50 | = | 26000.0 | nM | 4.58 | Inhibition of CYP2C8 (unknown origin) | 30429097 |
| Unchecked | IC50 | = | 26600.0 | nM | 4.58 | Competitive Binding Assay: PPARγ binding is measured by a TR-FRET competitive bi... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30429097 | 10.1016/j.bmc.2018.10.033 | Peroxisome proliferator-activated receptor gamma | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| 8978836 | 10.1021/jm9605694 | Mus musculus | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Cytochrome P450 2C9 | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Cytochrome P450 2C8 | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Mus musculus | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | ADMET | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Rattus norvegicus | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Salmonella typhimurium | 1 |
| 30429097 | 10.1016/j.bmc.2018.10.033 | Mitochondrial pyruvate carrier 2 | 1 |
Data from ChEMBL 36 via Core Engine